Silvia C. Finnemann, Ph.D., says the benefits of antioxidants are most effective when consumed  from an early age. Photo by Janet Sassi
Silvia C. Finnemann, Ph.D., says the benefits of antioxidants are most effective when consumed
from an early age.
Photo by Janet Sassi

New research from a Fordham cell biologist suggests that a diet rich in antioxidants and begun at a
young age can significantly reduce age-related blindness.

Silvia C. Finnemann, Ph.D., associate professor in the Department of Biological Sciences, conducted the three-year-plus study by comparing the vision of three groups of mice fed differing diets.

One group received a diet rich in freeze-dried grapes, a fruit very high in anti-oxidants. Another group received a diet rich in lutein, an antioxidant derived naturally from marigolds. The third group, the control group, received a normal diet.

All of the mice used were from the same genetic strain, said Finnemann—one prone to developing retinal damage in old age in much the same way that humans do.

Results showed that the mice in the control group experienced a 74 percent reduction in retinal function, while the mice fed the lutein-rich diet experienced a 29 percent reduction in retinal function.

The mice that were fed a grape-rich diet, however, did dramatically well: retinal function decreased by only 16 percent.

“We’re not suggesting that you need to eat grapes like crazy, but that a life of having a healthy diet of natural antioxidants makes a difference to changes in the human eye,” Finnemann said.

Finnemann’s study also showed that, to be effective, eating antioxidant-rich foods should begin before the onset of advanced age, preferably in youth or young adulthood.

Mice who were not fed a grape- and lutein-rich diet until they were the equivalent of a human age of 60 showed little or no improved retinal function, she said.

“Once the changes have started to happen, it may be too late to reverse them,” she said.

According to statistics, age-related macular degeneration (AMD) is the leading cause of blindness or partial blindness in the elderly, affecting about 25 percent of the population over 70 years of age in the United States. Finnemann said she hopes her study will lead to the development of new ways to prevent AMD, especially among the burgeoning elderly population of baby boomers.

“Our research shows that, when it comes to AMD, a healthy diet may be better than supplements, and the earlier you begin it, the better the results,” she concluded.

Finnemann’s research assistants include Chia-Chia Yu, M.S., and Ying Dun, Ph.D., both from her laboratory at Fordham; and Emeline Nandrot, Ph.D., a biologist from the Paris-based Institut de la Vision.

Funding was provided by the National Eye Institute of the National Institutes of Health, and the California Table Grape Commission.

Results of the study were published in December 2011 in Free Radical Biology & Medicine.